Calcium Alpha-Ketoglutarate Monohydrate (AKG-Ca)

1. Product Overview

Calcium Alpha-Ketoglutarate Monohydrate, commonly known as AKG-Ca Monohydrate, is the calcium salt of alpha-ketoglutaric acid, an organic compound involved in cellular energy metabolism. Alpha-ketoglutarate is an important intermediate in the tricarboxylic acid (TCA) cycle, which plays a central role in cellular energy production and metabolic processes.

By combining alpha-ketoglutarate with calcium, AKG-Ca provides a form of this organic acid suitable for specialized ingredient development and formulation research.

Calcium Alpha-Ketoglutarate is of interest to the nutritional ingredient industry because of the biological functions of alpha-ketoglutarate and the nutritional importance of calcium. Its potential applications depend on the product's specifications, purity, stability, regulatory status, and intended use.

Khonor Chemicals supplies specialty chemical and nutritional ingredient solutions to international customers, with a focus on product consistency, competitive pricing, quality control, and responsive service.

Product Name: Calcium Alpha-Ketoglutarate Monohydrate

Abbreviation: AKG-Ca Monohydrate

Alternative Name: Calcium 2-Oxoglutarate Monohydrate

Chemical Category: Organic Calcium Salt

Appearance: Typically a white to off-white powder; confirm against the actual product specification.

CAS Number: To be confirmed according to the exact chemical form supplied.

Molecular Formula: To be confirmed according to the calcium-to-alpha-ketoglutarate ratio and hydration state.

Molecular Weight: Depends on the confirmed molecular formula.

2. What Is Alpha-Ketoglutarate?

Alpha-ketoglutarate, also known as 2-oxoglutarate, is a naturally occurring organic molecule found in many living cells. It is a key intermediate in the TCA cycle, also known as the citric acid cycle or Krebs cycle.

This metabolic pathway helps cells process nutrients and generate energy. Alpha-ketoglutarate also participates in amino acid metabolism and serves as a substrate for various enzymes involved in cellular biochemical reactions.

Because of these functions, alpha-ketoglutarate has attracted scientific interest in areas such as metabolic research, nutritional ingredient development, and the study of physiological aging.

Calcium Alpha-Ketoglutarate combines alpha-ketoglutarate with calcium to create a salt form that can be evaluated for specific formulation requirements.

3. How Does Calcium Alpha-Ketoglutarate Work?

The biological relevance of AKG-Ca is associated primarily with the functions of its constituent components.

A. Role of Alpha-Ketoglutarate in Energy Metabolism

Alpha-ketoglutarate participates in the TCA cycle, a fundamental metabolic pathway that supports the production of cellular energy. During this cycle, metabolic intermediates are converted through a series of enzyme-catalyzed reactions that support the generation of reducing equivalents used in ATP production.

B. Role in Amino Acid Metabolism

Alpha-ketoglutarate participates in transamination reactions and other metabolic processes involving amino acids. It is closely connected with glutamate metabolism and the movement of nitrogen between biochemical pathways.

C. Role in Enzyme-Catalyzed Reactions

Alpha-ketoglutarate serves as a co-substrate for several classes of enzymes, including certain dioxygenases involved in processes such as the modification of proteins and the regulation of gene expression.

D. Contribution of Calcium

Calcium is an essential mineral involved in bone structure, muscle contraction, nerve signaling, and other physiological functions. The amount of calcium supplied by AKG-Ca depends on its confirmed chemical composition and purity.

These biochemical functions explain the scientific interest in alpha-ketoglutarate. However, they should not be interpreted as proof that supplementation with AKG-Ca produces specific clinical benefits in humans.

4. Potential Applications of AKG-Ca

A. Nutritional Ingredient Development

Calcium Alpha-Ketoglutarate may be evaluated as a specialized ingredient for nutritional product development, subject to the applicable regulatory requirements and the manufacturer's product grade.

B. Dietary Supplement Research

AKG-based compounds have attracted interest in research involving metabolism and healthy aging. However, evidence for one AKG compound or formulation cannot automatically be applied to calcium alpha-ketoglutarate monohydrate.

Any commercial dietary supplement application should be supported by appropriate safety assessments, ingredient specifications, and authorization for the intended market.

C. Biochemical and Metabolic Research

AKG-Ca may be considered for research and development projects investigating alpha-ketoglutarate-related biochemical pathways, provided the material meets the relevant research requirements.

D. Specialized Ingredient Formulation

Depending on its solubility, stability, purity, and compatibility with other ingredients, AKG-Ca may be assessed for use in specialized formulations. Suitability should be determined through formulation trials and stability testing.

5. Calcium Alpha-Ketoglutarate vs. Other AKG Forms

Alpha-ketoglutarate can be supplied in different chemical forms, depending on the counterion and intended application.

Calcium Alpha-Ketoglutarate (AKG-Ca): A calcium salt that may be considered when both the alpha-ketoglutarate component and calcium content are relevant to formulation design.

Arginine Alpha-Ketoglutarate (AAKG): An arginine salt commonly associated with sports nutrition ingredient development.

Alpha-Ketoglutaric Acid (AKG Acid): The free-acid form, which differs from its mineral salts in chemical composition and formulation characteristics.

These ingredients are not interchangeable on a weight-for-weight basis. Their molecular composition, solubility, mineral contribution, stability, and application requirements should be evaluated individually.

6. Manufacturing Process

The production of Calcium Alpha-Ketoglutarate generally involves controlled chemical processing to obtain the desired calcium salt. The exact manufacturing route depends on the specified stoichiometry, hydration state, raw materials, and target purity.

Typical production stages may include:

1. Raw Material Preparation: Qualified alpha-ketoglutaric acid or an appropriate alpha-ketoglutarate source and a suitable calcium-containing raw material are selected according to the approved manufacturing process.

2. Reaction and pH Control: The reactants are processed under controlled conditions to promote salt formation and achieve the desired chemical composition.

3. Purification and Separation: The reaction mixture may undergo clarification, filtration, or other suitable purification operations to remove unwanted impurities.

4. Crystallization: Controlled crystallization may be used to obtain the required product form and hydration state.

5. Drying and Milling: The isolated material is dried under appropriate conditions and processed to achieve the target moisture content and particle-size distribution.

6. Quality Testing: The finished product is evaluated against the manufacturer's approved specifications before release.

The actual manufacturing route may differ by producer. Reaction conditions, purification methods, and crystallization parameters should not be assumed without confirmation from the manufacturer.

7. Raw Materials and Quality Control

The quality of Calcium Alpha-Ketoglutarate depends on the quality of its raw materials and the control of the manufacturing process.

Key quality considerations include:

• Raw Material Quality: Verification of identity, purity, and suitability of the starting materials.

• Chemical Composition: Confirmation of the calcium-to-alpha-ketoglutarate ratio and hydration state.

• Assay: Testing according to an appropriate validated analytical method.

• Moisture Content: Monitoring water content or loss on drying, as applicable.

• Impurity Control: Assessment of relevant residual impurities and heavy metals.

• Physical Properties: Evaluation of appearance, particle size, and other agreed parameters.

• Batch Consistency: Comparison of results with the approved product specification.

The specific testing methods and acceptance limits should be established by the manufacturer and documented in the applicable technical specification and Certificate of Analysis (COA).

8. Storage and Handling

Calcium Alpha-Ketoglutarate Monohydrate should be stored in a tightly sealed package in a cool, dry, and well-ventilated environment.

Recommended handling practices include:

• Protect the product from moisture and direct sunlight.

• Keep containers closed when not in use.

• Avoid contamination during sampling and repackaging.

• Use appropriate personal protective equipment in accordance with the Safety Data Sheet (SDS).

• Follow the manufacturer's instructions for shelf life and storage conditions.

Actual storage requirements and shelf life should be confirmed using the supplier's stability data.

9. Packaging and Supply

Khonor Chemicals can discuss packaging and supply arrangements according to customer requirements and the confirmed product specification.

Typical industrial ingredient packaging may include lined bags or other moisture-protective packaging, subject to the actual product, available packaging format, and shipping requirements.

Available packaging sizes, minimum order quantities, lead times, sample availability, and customized labeling should be confirmed with our sales team.

Customers are encouraged to specify their intended application, required grade, target market, and technical requirements when requesting a quotation.

10. Why Choose Khonor Chemicals?

Jiangsu Khonor Chemicals Co.,Limited is an international chemical trading and supply company serving customers across multiple chemical and nutritional ingredient categories.

Our approach focuses on practical sourcing solutions and long-term business cooperation.

• Competitive Pricing: We work with qualified supply partners to provide commercially competitive offers.

• Quality Control: Product specifications and batch documentation can be coordinated according to customer requirements.

• Flexible Sourcing: Our supply network covers a range of food ingredients, feed additives, water treatment chemicals, fertilizers, and specialty chemicals.

• Responsive Communication: We aim to respond promptly to technical and commercial inquiries.

• Export Experience: We support international customers with product documentation, packaging coordination, and export arrangements.

• Customer-Oriented Service: We work to identify suitable products and supply solutions based on each customer's market and application needs.

For Calcium Alpha-Ketoglutarate Monohydrate, final availability, specifications, regulatory documentation, and commercial terms are subject to confirmation.

11. Frequently Asked Questions

Q1: What is Calcium Alpha-Ketoglutarate?

Calcium Alpha-Ketoglutarate is a calcium salt of alpha-ketoglutaric acid, a compound involved in the TCA cycle and amino acid metabolism.

Q2: What is AKG-Ca used for?

Potential uses include specialized ingredient development and biochemical research. Any nutritional supplement application depends on product suitability and the applicable regulations in the target market.

Q3: Is Calcium Alpha-Ketoglutarate the same as AAKG?

No. Calcium Alpha-Ketoglutarate contains calcium, whereas AAKG refers to arginine alpha-ketoglutarate. Their chemical composition and formulation characteristics differ.

Q4: Is AKG-Ca suitable for dietary supplements?

Its suitability depends on the specific product grade, safety documentation, intended use, and regulatory status in the destination market. Customers should verify these factors before commercial use.

Q5: How should AKG-Ca be stored?

Store in a tightly sealed container in a cool, dry place and follow the manufacturer's recommended storage conditions.

Q6: Can Khonor provide a COA and TDS?

Technical documentation may be available according to the confirmed product and supplier documentation. Please contact Khonor Chemicals to request the current TDS, COA, and other relevant documents.

12. Contact Khonor Chemicals

Looking for a reliable supply solution for Calcium Alpha-Ketoglutarate Monohydrate?

Contact Jiangsu Khonor Chemicals Co.,Limited to discuss product specifications, packaging, samples, and quotations.

Website: www.khonorchem.com

Contact our sales team for current product availability, technical documentation, and customized supply arrangements.

COA - Ca-AKG.pdf

TDS - Ca-AKG.pdf